The recognized impact of such PTMs on ATXN2’s operate and SCA2 pathogenesis remains restricted. In other polyQ diseases, multiple studies suggested that proteolytic cleavage of polyQ proteins could Participate in a very important job in pathogenesis [36, forty five]. Aligned with this strategy, the presence of an enriched forty two kDa https://znl-02-09624578.blog2news.com/28840178/considerations-to-know-about-isa-2011b