Opioid activity is due to both minimal affinity binding on the parent compound and better affinity binding on the O-demethylated metabolite M1 to μ-opioid receptors. In animal types, M1 is as much as 6 occasions more potent than tramadol in generating analgesia and 200 periods extra strong in μ-opioid binding. https://derrickq123ecy1.wikimeglio.com/user