Pentobarbital will lower the level or effect of imatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unidentified. pentobarbital will reduce the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is really a sensitive CYP3A4 substrate. Coadministration with solid or reasonable CYP3A4 in... https://pauld937cgn0.wikiusnews.com/user